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Article

RNA folding in Drosophila shows a distance effect for compensatory fitness interactions.

Genetics - 1 Sept 1993

Stephan W, Kirby D A

Abstract excerpt

Phylogenetic-comparative analysis was used to construct a secondary structure of Adh precursor messenger RNA (pre-mRNA) in Drosophila. The analysis revealed that the rate of coevolution of base-pairing residues decreases with their physical distance. This result is in qualitative agreement with a model of compensatory fitness interactions which assumes that mutations are individually deleterious but become...

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Identifiers

PMID: 8224831
DOI: 10.1093/genetics/135.1.97
PMCID: PMC1205630

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Source receipt: pubmed, retrieved 7 Sept 2026.

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