Article
RNA secondary structure and compensatory evolution.
Genes & genetic systems - 1 Dec 1999
Chen Y, Carlini D B, Baines J F, Parsch J, Braverman J M, Tanda S, Stephan W
Abstract excerpt
The classic concept of epistatic fitness interactions between genes has been extended to study interactions within gene regions, especially between nucleotides that are important in maintaining pre-mRNA/mRNA secondary structures. It is shown that the majority of linkage disequilibria found within the Drosophila Adh gene are likely to be caused by epistatic selection operating on RNA secondary structures. A...
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