Article
Compensatory mutations cause excess of antagonistic epistasis in RNA secondary structure folding.
BMC evolutionary biology - 5 Feb 2003
Wilke Claus O, Lenski Richard E, Adami Christoph
Abstract excerpt
BACKGROUND: The rate at which fitness declines as an organism's genome accumulates random mutations is an important variable in several evolutionary theories. At an intuitive level, it might seem natural that random mutations should tend to interact synergistically, such that the rate of mean fitness decline accelerates as the number of random mutations is increased. However, in a number of recent studies, a...
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