Selection intensity against deleterious mutations in RNA secondary structures and rate of compensatory nucleotide substitutions.

Abstract excerpt

A two-locus model of reversible mutations with compensatory fitness interactions is presented; single mutations are assumed to be deleterious but neutral in appropriate combinations. The expectation of the time of compensatory nucleotide substitutions is calculated analytically for the case of tight linkage between sites. It is shown that selection increases the substitution time dramatically when selection...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to 3' Untranslated Regions
• Share to Diploidy
• Share to Drosophila