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Article

Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents

14 Sept 1999

Abstract excerpt

All cells are unavoidably exposed to chemicals that can alkylate DNA to form genotoxic damage. Among the various DNA lesions formed, O(6)-alkylguanine lesions can be highly cytotoxic, and we recently demonstrated that O(6)-methylguanine (O(6)MeG) and O(6)-chloroethylguanine (O(6)CEG) specifically initiate apoptosis in hamster cells. Here we show, in both hamster and human cells, that the MutSalpha branch of the...

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PMID: 10485900
DOI: 10.1073/pnas.96.19.10764

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