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Article

dUTP pyrophosphatase is an essential enzyme in Saccharomyces cerevisiae.

The EMBO journal - 1 Nov 1993

Gadsden M H, McIntosh E M, Game J C, Wilson P J, Haynes R H

Abstract excerpt

dUTP pyrophosphatase (dUTPase; EC 3.6.1.23) catalyses the hydrolysis of dUTP to dUMP and PPi and thereby prevents the incorporation of uracil into DNA during replication. Although it is widely believed that dUTPase is essential for cell viability because of this role, direct evidence supporting this assumption has not been presented for any eukaryotic system. We have analysed the role of dUTPase (DUT1) in the...

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Identifiers

PMID: 8223452
DOI: 10.1002/j.1460-2075.1993.tb06127.x
PMCID: PMC413740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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