Article
dUTP pyrophosphatase is an essential enzyme in Saccharomyces cerevisiae.
The EMBO journal - 1 Nov 1993
Gadsden M H, McIntosh E M, Game J C, Wilson P J, Haynes R H
Abstract excerpt
dUTP pyrophosphatase (dUTPase; EC 3.6.1.23) catalyses the hydrolysis of dUTP to dUMP and PPi and thereby prevents the incorporation of uracil into DNA during replication. Although it is widely believed that dUTPase is essential for cell viability because of this role, direct evidence supporting t...
Topics
- Amino Acid Sequence
- Base Sequence
- Cell Cycle
- Chromosome Mapping
- Chromosomes, Fungal
- Cloning, Molecular
- Crosses, Genetic
- DNA Glycosylases
- DNA Repair
- Genes, Fungal
- Genes, Lethal
- Molecular Sequence Data
- Mutagenesis, Insertional
- Mutation
- N-Glycosyl Hydrolases
- Pyrophosphatases
- Saccharomyces cerevisiae
- Sequence Analysis, DNA