dUTPase is essential in zebrafish development and possesses several single-nucleotide variants with pronounced structural and functional consequences.

doi:10.1002/2211-5463.70176

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Article

dUTPase is essential in zebrafish development and possesses several single-nucleotide variants with pronounced structural and functional consequences.

FEBS open bio - 1 Jun 2026

Perey-Simon Viktória, Békesi Angéla, Kazzazy Latifa, Mihály Jázmin, Varga Máté, Vértessy Beáta G, Nyíri Kinga

Abstract excerpt

Genome stability and faithful DNA replication are essential for cell viability. Numerous interlinked pathways in DNA damage recognition, repair and maintenance of physiologically competent nucleotide pools contribute to providing a solid framework to uphold DNA integrity. The enzyme family of dUTPases is involved in balancing the appropriate nucleotide pools by removing dUTP from the cellular milieu and providing...

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PMID: 41400157
DOI: 10.1002/2211-5463.70176
PMCID: PMC13238773

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