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Article

The dUTPase enzyme is essential in Mycobacterium smegmatis.

PloS one - 1 Jan 2012

Pecsi Ildiko, Hirmondo Rita, Brown Amanda C, Lopata Anna, Parish Tanya, Vertessy Beata G, Tóth Judit

Abstract excerpt

Thymidine biosynthesis is essential in all cells. Inhibitors of the enzymes involved in this pathway (e.g. methotrexate) are thus frequently used as cytostatics. Due to its pivotal role in mycobacterial thymidylate synthesis dUTPase, which hydrolyzes dUTP into the dTTP precursor dUMP, has been suggested as a target for new antitubercular agents. All mycobacterial genomes encode dUTPase with a...

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Identifiers

PMID: 22655049
DOI: 10.1371/journal.pone.0037461
PMCID: PMC3360063

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