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Increased uracil insertion in DNA is cytotoxic and increases the frequency of mutation, double strand break formation and VSG switching in Trypanosoma brucei.

DNA repair - 1 Dec 2012

Castillo-Acosta Víctor M, Aguilar-Pereyra Fernando, Bart Jean-Mathieu, Navarro Miguel, Ruiz-Pérez Luis M, Vidal Antonio E, González-Pacanowska Dolores

Abstract excerpt

Deoxyuridine 5'-triphosphate pyrophosphatase (dUTPase) and uracil-DNA glycosylase (UNG) are key enzymes involved in the control of the presence of uracil in DNA. While dUTPase prevents uracil misincorporation by removing dUTP from the deoxynucleotide pool, UNG excises uracil from DNA as a first step of the base excision repair pathway (BER). Here, we report that strong down-regulation of dUTPase in UNG-deficient...

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Source

Identifiers

PMID: 23085192
DOI: 10.1016/j.dnarep.2012.09.007

Genes

UNG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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