Article
Activation of an MAP kinase cascade leads to Sir3p hyperphosphorylation and strengthens transcriptional silencing.
The Journal of cell biology - 1 Nov 1996
Stone E M, Pillus L
Abstract excerpt
During cell division and growth, the nucleus and chromosomes are remodeled for DNA replication and cell type-specific transcriptional control. The yeast silencing protein Sir3p functions in both chromosome structure and in transcriptional regulation. Specifically, Sir3p is critical for the mainte...
Topics
- Calcium-Calmodulin-Dependent Protein Kinases
- Enzyme Activation
- Fungal Proteins
- G1 Phase
- Gene Expression Regulation, Fungal
- Heat-Shock Response
- Mating Factor
- Mutation
- Peptides
- Pheromones
- Phosphoproteins
- Phosphorylation
- Saccharomyces cerevisiae
- Signal Transduction
- Silent Information Regulator Proteins, Saccharomyces cerevisiae
- Telomere
- Trans-Activators
- Transcription, Genetic