Linkage analysis of DRD2, a marker linked to the ataxia-telangiectasia gene, in 64 families with premenopausal bilateral breast cancer.

Article

Linkage analysis of DRD2, a marker linked to the ataxia-telangiectasia gene, in 64 families with premenopausal bilateral breast cancer.

Cancer research - 1 Nov 1993

Cortessis V, Ingles S, Millikan R, Diep A, Gatti R A, Richardson L, Thompson W D, Paganini-Hill A, Sparkes R S, Haile R W

Abstract excerpt

Recent reports suggest that subjects who are heterozygous for the ataxia-telangiectasia gene are at increased risk of breast cancer. We conducted linkage analyses of 64 families with premenopausal bilateral breast cancer using DRD2, a marker linked to the ataxia-telangiectasia locus at 11q22-23. We assumed a model with dominant transmission of breast cancer. Lod scores summed over all families provided strong...

Topics

Adult
Alleles
Ataxia Telangiectasia
Base Sequence
Breast Neoplasms
Chromosome Mapping
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 17
DNA Primers
Female

Genetic Linkage

Genetic Markers

Genetic Predisposition to Disease

Humans

Lod Score

Middle Aged

Molecular Sequence Data

Ovarian Neoplasms

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest

Linkage analysis of DRD2, a marker linked to the ataxia-telangiectasia gene, in 64 families with premenopausal bilateral breast cancer.PMID 8221639Read

Linkage to BRCA2 region in hereditary male breast cancer.Semantic proximity Read

Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibility.Semantic proximity Read

A genome wide linkage search for breast cancer susceptibility genes.Semantic proximity Read

Inherited breast cancer.Semantic proximity Read

BRCA1 and BRCA2 and breast cancer incidence: a review.Semantic proximity Read

BRCA1 and BRCA2: from molecular genetics to clinical medicine.Semantic proximity Read

Genome-wide linkage scan for breast cancer susceptibility loci in Swedish hereditary non-BRCA1/2 families: suggestive linkage to 10q23.32-q25.3.Semantic proximity Read

Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium.Semantic proximity Read