Article
Linkage analysis of DRD2, a marker linked to the ataxia-telangiectasia gene, in 64 families with premenopausal bilateral breast cancer.
Cancer research - 1 Nov 1993
Cortessis V, Ingles S, Millikan R, Diep A, Gatti R A, Richardson L, Thompson W D, Paganini-Hill A, Sparkes R S, Haile R W
Abstract excerpt
Recent reports suggest that subjects who are heterozygous for the ataxia-telangiectasia gene are at increased risk of breast cancer. We conducted linkage analyses of 64 families with premenopausal bilateral breast cancer using DRD2, a marker linked to the ataxia-telangiectasia locus at 11q22-23. We assumed a model with dominant transmission of breast cancer. Lod scores summed over all families provided strong...
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