BRCA1 and BRCA2: from molecular genetics to clinical medicine.

doi:10.1200/JCO.1998.16.5.1969

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Article

BRCA1 and BRCA2: from molecular genetics to clinical medicine.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 May 1998

Blackwood M A, Weber B L

Abstract excerpt

Inherited susceptibility to breast cancer has been an area of intense investigation for the past 10 years. Early work focused on identifying modes of transmission, which culminated in the identification of chromosome 17q12-21 as the first human genomic region that harbored an autosomal dominant s...

Topics

Animals
BRCA2 Protein
Breast Neoplasms
Female
Genes, BRCA1
Genes, Tumor Suppressor
Genetic Markers
Genetic Predisposition to Disease
Germ-Line Mutation
Humans
Neoplasm Proteins
Ovarian Neoplasms
Transcription Factors

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