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Article

Interaction between PRP11 and SPP91 yeast splicing factors and characterization of a PRP9-PRP11-SPP91 complex.

Science (New York, N.Y.) - 1 Oct 1993

Legrain P, Chapon C

Abstract excerpt

Several proteins are involved in the early steps of the spliceosome assembly pathway. Protein-protein interactions have been identified between two Saccharomyces cerevisiae yeast splicing factors, PRP9 and SPP91. Here it is demonstrated that protein-protein interactions occur between SPP91 and PRP11. The combination of the prp9-1 mutant and a truncated prp11 mutant exhibits a synthetic lethal phenotype,...

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Identifiers

PMID: 8211114
DOI: 10.1126/science.8211114

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Interaction between PRP11 and SPP91 yeast splicing factors and characterization of a PRP9-PRP11-SPP91 complex.PMID 8211114Read ↗

Interactions between PRP9 and SPP91 splicing factors identify a protein complex required in prespliceosome assembly.Semantic proximity Read ↗

Four yeast spliceosomal proteins (PRP5, PRP9, PRP11, and PRP21) interact to promote U2 snRNP binding to pre-mRNA.Semantic proximity Read ↗

A novel gene, spp91-1, suppresses the splicing defect and the pre-mRNA nuclear export in the prp9-1 mutant.Semantic proximity Read ↗

Snt309p, a component of the Prp19p-associated complex that interacts with Prp19p and associates with the spliceosome simultaneously with or immediately after dissociation of U4 in the same manner as Prp19p.Semantic proximity Read ↗

A suppressor of a yeast splicing mutation (prp8-1) encodes a putative ATP-dependent RNA helicase.Semantic proximity Read ↗

Functional and physical interactions between components of the Prp19p-associated complex.Semantic proximity Read ↗

The molecular characterization of PRP6 and PRP9 yeast genes reveals a new cysteine/histidine motif common to several splicing factors.Semantic proximity Read ↗

Inhibition of a spliceosome turnover pathway suppresses splicing defects.Semantic proximity Read ↗

The Saccharomyces cerevisiae PRP21 gene product is an integral component of the prespliceosome.Semantic proximity Read ↗

Extragenic suppressors of Saccharomyces cerevisiae prp4 mutations identify a negative regulator of PRP genes.Semantic proximity Read ↗

Distinct domains of splicing factor Prp8 mediate different aspects of spliceosome activation.Semantic proximity Read ↗

How Slu7 and Prp18 cooperate in the second step of yeast pre-mRNA splicing.Semantic proximity Read ↗

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