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Article

p53 and a human premature ageing disorder.

Mechanisms of ageing and development - 1 May 2003

O'Neill Mary, Núñez Fatima, Melton David W

Abstract excerpt

It has been shown that enhanced levels of p53 activity contribute to reduced cancer susceptibility in mice, however longevity is compromised due to the onset of an early-ageing phenotype. The effects of enhanced levels of p53 in these in mice could therefore have implications for human premature ageing disorders. We examined the DNA damage response of p53 and its target p21(WAF1) to UV and ionising radiation in...

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Identifiers

PMID: 12735900
DOI: 10.1016/s0047-6374(03)00007-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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