Article
Cooperative actions of HIV-1 Vpr and p53 modulate viral gene transcription.
The Journal of biological chemistry - 7 Aug 1998
Sawaya B E, Khalili K, Mercer W E, Denisova L, Amini S
Abstract excerpt
Transcription of the human immunodeficiency virus type-1 (HIV-1) genome is controlled by cooperative interaction of viral encoded proteins and host regulatory proteins. In this study, we have examined the capacity of the viral auxiliary protein, Vpr, to modulate transcriptional activity of the HI...
Topics
- Astrocytes
- Gene Expression Regulation, Viral
- Gene Products, vpr
- HIV Long Terminal Repeat
- HIV-1
- Humans
- Mutation
- Sp1 Transcription Factor
- Suppression, Genetic
- Transcription, Genetic
- Transcriptional Activation
- Transfection
- Tumor Suppressor Protein p53
- Viral Proteins
- vpr Gene Products, Human Immunodeficiency Virus