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Article

Broad and Dynamic Diversification of Infectious Hepatitis C Virus in a Cell Culture Environment.

Journal of virology - 28 Feb 2020

Gallego Isabel, Soria María Eugenia, García-Crespo Carlos, Chen Qian, Martínez-Barragán Patricia, Khalfaoui Soumaya, Martínez-González Brenda, Sanchez-Martin Irene, Palacios-Blanco Inés, de Ávila Ana Isabel, García-Cehic Damir, Esteban Juan Ignacio, Gómez Jordi, Briones Carlos, Gregori Josep, Quer Josep, Perales Celia, Domingo Esteban

Abstract excerpt

Previous studies documented that long-term hepatitis C virus (HCV) replication in human hepatoma Huh-7.5 cells resulted in viral fitness gain, expansion of the mutant spectrum, and several phenotypic alterations. In the present work, we show that mutational waves (changes in frequency of individual mutations) occurred continuously and became more prominent as the virus gained fitness. They were accompanied by an...

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Identifiers

PMID: 31852791
DOI: 10.1128/JVI.01856-19
PMCID: PMC7158725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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