Article
Intracellular formation and cell surface expression of a complex of an intact lysosomal protein and MHC class II molecules.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1998
Arunachalam B, Pan M, Cresswell P
Abstract excerpt
The generation of invariant chain-free MHC class II molecules and their association with endocytically generated peptides are thought to occur in specialized lysosome-like compartments called MIICs (MHC class II compartments). A number of in vitro studies have shown that large denatured proteins...
Topics
- Alleles
- Animals
- Cell Transformation, Viral
- Electrophoresis, Polyacrylamide Gel
- Flow Cytometry
- Fluorescent Antibody Technique, Indirect
- HLA-D Antigens
- HLA-DR Antigens
- Herpesvirus 4, Human
- Histocompatibility Antigens Class II
- Lysosomes
- Mice
- Oxidoreductases
- Oxidoreductases Acting on Sulfur Group Donors
- Proteins
- Rabbits
- Sodium Dodecyl Sulfate
- Surface Properties