Article
Structural integrity of the Golgi is temperature sensitive in conditional-lethal mutants with no detectable GM130.
Traffic (Copenhagen, Denmark) - 1 Apr 2003
Vasile Eliza, Perez Tomas, Nakamura Nobuhiro, Krieger Monty
Abstract excerpt
At 39.5 degrees C in the temperature-sensitive, conditional-lethal mutant ldlG, glycoprotein processing is disrupted and secretion is blocked. The ultrastructure of the Golgi apparatus in ldlG cells was examined using immunofluorescence and immunoelectron microscopy. At 34 degrees C the structure of the Golgi apparatus was normal, whereas after incubation at 39.5 degrees C for 12 h it disassembled into dispersed...
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