Imprinting and X chromosome counting mechanisms determine Xist expression in early mouse development.

doi:10.1016/0092-8674(94)90049-3

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Article

Imprinting and X chromosome counting mechanisms determine Xist expression in early mouse development.

Cell - 3 Jun 1994

Kay G F, Barton S C, Surani M A, Rastan S

Abstract excerpt

In mice, X inactivation is preceded by in cis Xist expression. Initially, normal female embryos express the paternal Xist allele exclusively, preceding imprinted X inactivation in the trophectoderm. Later expression of Xist alleles is random, preceding random X inactivation in the epiblast lineag...

Topics

Alleles
Animals
Dosage Compensation, Genetic
Embryonic and Fetal Development
Female
Gene Expression
Genes, Switch
Male
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Parthenogenesis
X Chromosome
Y Chromosome

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