Article
Imprinting and X chromosome counting mechanisms determine Xist expression in early mouse development.
Cell - 3 Jun 1994
Kay G F, Barton S C, Surani M A, Rastan S
Abstract excerpt
In mice, X inactivation is preceded by in cis Xist expression. Initially, normal female embryos express the paternal Xist allele exclusively, preceding imprinted X inactivation in the trophectoderm. Later expression of Xist alleles is random, preceding random X inactivation in the epiblast lineage. In this study using uniparental embryos, we demonstrate that Xist expression is initially dictated solely by...
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