Article
Expression of Xist during mouse development suggests a role in the initiation of X chromosome inactivation.
Cell - 29 Jan 1993
Kay G F, Penny G D, Patel D, Ashworth A, Brockdorff N, Rastan S
Abstract excerpt
The mouse Xist gene maps to the X inactivation center (Xic) region and is expressed exclusively from the inactive X chromosome. It is thus a candidate gene for the Xic. We show that the onset of Xist expression in mouse development precedes X chromosome inactivation and may therefore be a cause rather than merely a consequence of X inactivation. The earliest Xist expression in morulae and blastocysts is...
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