Article
Changes in growth and tumorigenicity following reconstitution of retinoblastoma gene function in various human cancer cell types by microcell transfer of chromosome 13.
Cancer research - 15 Nov 1992
Banerjee A, Xu H J, Hu S X, Araujo D, Takahashi R, Stanbridge E J, Benedict W F
Abstract excerpt
Functional loss of the retinoblastoma (RB) gene has been implicated in the initiation or progression of several human tumor types including cancer of the eye, bone, bladder, and prostate. To examine the consequence of adding one RB allele containing its normal regulatory elements back into repres...
Topics
- Alleles
- Animals
- Cell Division
- Chromosomes, Human, Pair 13
- DNA
- Gene Expression
- Genes, Retinoblastoma
- Humans
- Male
- Mice
- Neomycin
- Neoplasms, Experimental
- Osteosarcoma
- Plasmids
- Prostatic Neoplasms
- Retinoblastoma
- Retroviridae
- Transfection