Article
Multiple loci on human chromosome 11 control tumorigenicity of BK virus transformed cells.
International journal of cancer - 15 Apr 1994
Sabbioni S, Negrini M, Possati L, Bonfatti A, Corallini A, Sensi A, Stanbridge E J, Barbanti-Brodano G
Abstract excerpt
BK virus (BKV) is a human papovavirus that readily transforms rodent cells, but not human cells, to a neoplastic phenotype, suggesting that tumor-suppressor functions expressed in human cells control BKV oncogenicity. Transfer of a normal human chromosome 11 to BKV-transformed mouse cells suppresses the malignant phenotype. In this report we map the regions of chromosome 11 involved in tumor suppression. Transfer...
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