Article
Multiple loci on human chromosome 11 control tumorigenicity of BK virus transformed cells.
International journal of cancer - 15 Apr 1994
Sabbioni S, Negrini M, Possati L, Bonfatti A, Corallini A, Sensi A, Stanbridge E J, Barbanti-Brodano G
Abstract excerpt
BK virus (BKV) is a human papovavirus that readily transforms rodent cells, but not human cells, to a neoplastic phenotype, suggesting that tumor-suppressor functions expressed in human cells control BKV oncogenicity. Transfer of a normal human chromosome 11 to BKV-transformed mouse cells suppres...
Topics
- Animals
- BK Virus
- Cell Line
- Cell Transformation, Neoplastic
- Chromosome Aberrations
- Chromosomes, Human, Pair 11
- Cricetinae
- Genes, Tumor Suppressor
- Humans
- Hybrid Cells
- Mice
- Neoplasms, Experimental
- Phenotype
