Article
Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene.
Science (New York, N.Y.) - 9 Feb 1990
Bookstein R, Shew J Y, Chen P L, Scully P, Lee W H
Abstract excerpt
Introduction of a normal retinoblastoma gene (RB) into retinoblastoma cells was previously shown to suppress several aspects of their neoplastic phenotype, including tumorigenicity in nude mice, thereby directly demonstrating a cancer suppression function of RB. To explore the possibility of a similar activity in a common adult tumor, RB expression was examined in three human prostate carcinoma cell lines. One of...
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