Article
Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene.
Science (New York, N.Y.) - 9 Feb 1990
Bookstein R, Shew J Y, Chen P L, Scully P, Lee W H
Abstract excerpt
Introduction of a normal retinoblastoma gene (RB) into retinoblastoma cells was previously shown to suppress several aspects of their neoplastic phenotype, including tumorigenicity in nude mice, thereby directly demonstrating a cancer suppression function of RB. To explore the possibility of a si...
Topics
- Animals
- Base Sequence
- DNA
- Gene Amplification
- Gene Expression
- Humans
- Male
- Mice
- Mice, Nude
- Molecular Sequence Data
- Mutation
- Nucleic Acid Hybridization
- Prostatic Neoplasms
- RNA, Messenger
- Retinoblastoma
- Suppression, Genetic
- Transfection
- Tumor Cells, Cultured