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Article

Relationship between plasma desipramine levels, CYP2D6 phenotype and clinical response to desipramine: a prospective study.

European journal of clinical pharmacology - 1 Jan 1997

Spina E, Gitto C, Avenoso A, Campo G M, Caputi A P, Perucca E

Abstract excerpt

OBJECTIVE: The clinical relevance of the CYP2D6 oxidation polymorphism in the treatment of depression with desipramine (DMI) was studied prospectively in depressed outpatients. METHODS: After CYP2D6 phenotype determination with dextromethorphan, 31 patients were treated with oral DMI at a dosage...

Topics

Adult
Antidepressive Agents, Tricyclic
Cytochrome P-450 CYP2D6
Depressive Disorder
Desipramine
Dextromethorphan
Female
Humans
Male
Middle Aged
Oxidation-Reduction
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Prospective Studies

Source

Identifiers

PMID: 9049581
DOI: 10.1007/s002280050220

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9049581-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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