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Article

The effects of desvenlafaxine and paroxetine on the pharmacokinetics of the cytochrome P450 2D6 substrate desipramine in healthy adults.

Journal of clinical pharmacology - 1 Feb 2009

Nichols Alice I, Fatato Penny, Shenouda Magdy, Paul Jeffrey, Isler Jennifer A, Pedersen Ronald D, Jiang Qin, Ahmed Saeeduddin, Patroneva Albena

Abstract excerpt

The potential for cytochrome P450 (CYP) 2D6 substrates to interact with desvenlafaxine (administered as desvenlafaxine succinate) and paroxetine was evaluated. In an open-label, crossover study, 20 healthy volunteers (aged 21-50) were randomized to 2 series of 9 days each of desvenlafaxine (100 mg/d) or paroxetine (20 mg/d), separated by a 5-day washout. The CYP2D6 substrate desipramine (50 mg) was administered...

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Source

Identifiers

PMID: 19001559
DOI: 10.1177/0091270008326716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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