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Article

Desipramine, substrate for CYP2D6 activity: population pharmacokinetic model and design elements of drug-drug interaction trials.

British journal of clinical pharmacology - 1 Oct 2010

Gueorguieva Ivelina, Jackson Kimberley, Wrighton Steven A, Sinha Vikram P, Chien Jenny Y

Abstract excerpt

AIMS: To develop a population pharmacokinetic model to describe the pharmacokinetics of desipramine in healthy subjects, after oral administration of a 50mg dose. Additional objectives were to develop a semi-mechanistic population pharmacokinetic model for desipramine, which allowed simulation of CYP2D6-mediated inhibition, when using desipramine as a probe substrate, and to evaluate certain study design...

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Identifiers

PMID: 20840444
DOI: 10.1111/j.1365-2125.2010.03731.x
PMCID: PMC2950987

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Source receipt: pubmed, retrieved 7 Sept 2026.

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