Polymorphic 2-hydroxylation of desipramine. A population and family study.

doi:10.1007/BF00315541

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Article

Polymorphic 2-hydroxylation of desipramine. A population and family study.

European journal of clinical pharmacology - 1 Jan 1993

Dahl M L, Iselius L, Alm C, Svensson J O, Lee D, Johansson I, Ingelman-Sundberg M, Sjöqvist F

Abstract excerpt

We have studied desipramine hydroxylation capacity, determined as the metabolic ratio of desipramine to 2-hydroxydesipramine in the urine after a single oral dose of 10 mg of desipramine, in 340 Swedish Caucasians, including the members of 45 two-generation families. Desipramine metabolic ratios...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Antidepressive Agents, Tricyclic
Child
Debrisoquin
Desipramine
Female
Genetic Linkage
Genotype
Humans
Hydroxylation
Male
Middle Aged
Phenotype
Polymorphism, Genetic
Sweden

Source

Open in PubMed

Identifiers

PMID: 8359181
DOI: 10.1007/BF00315541

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8359181-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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