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Article

Metabolism of desipramine in Japanese psychiatric patients: the impact of CYP2D6 genotype on the hydroxylation of desipramine.

Pharmacology & toxicology - 1 Jun 2000

Shimoda K, Morita S, Hirokane G, Yokono A, Someya T, Takahashi S

Abstract excerpt

We investigated the impact of the genotype of CYP2D6 on the hydroxylation of desipramine in eighteen patients who were administered desipramine hydrochloride per os. Significantly higher plasma concentration of desipramine/daily dose of desipramine/body weight was observed in the subjects with two mutated alleles than in the subjects with either no mutated alleles or one mutated allele (two mutated alleles versus...

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Source

Identifiers

PMID: 10895986
DOI: 10.1111/j.0901-9928.2000.860601.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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