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Article

Stabilization and enhanced enzymatic activities of a mutant human lysozyme C77/95A with a cavity space by amino acid substitution.

Biological & pharmaceutical bulletin - 1 Feb 1994

Yamada H, Kanaya E, Inaka K, Ueno Y, Ikehara M, Kikuchi M

Abstract excerpt

Amino acid substitutions were examined to increase the stability of the mutant human lysozyme C77/95A by filling the cavity created by this mutation. To modulate the cavity with hydrophobic amino acids or by the formation of a hydrogen bond, five amino acid-substituted mutants, C77AC95L, C77AC95I...

Topics

Base Sequence
Chromatography, High Pressure Liquid
Enzyme Activation
Enzyme Stability
Humans
Hydrogen Bonding
Hydrogen-Ion Concentration
Leucine
Molecular Sequence Data
Muramidase
Mutation
Serine

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Identifiers

PMID: 8205114
DOI: 10.1248/bpb.17.192

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8205114-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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