Reversal of the human and murine multidrug-resistance phenotype with megestrol acetate.

doi:10.1007/BF00685925

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Article

Reversal of the human and murine multidrug-resistance phenotype with megestrol acetate.

Cancer chemotherapy and pharmacology - 1 Jan 1994

Wang L, Yang C P, Horwitz S B, Trail P A, Casazza A M

Abstract excerpt

MA is an orally active PG derivative with an excellent safety profile that is used primarily for the treatment of carcinomas of the breast and endometrium. We investigated the potential application of MA as an MDR-reversal agent using cell culture and human tumor xenograft models. The reversing a...

Topics

Animals
Antineoplastic Combined Chemotherapy Protocols
Breast Neoplasms
Carcinoma
Chemotherapy, Adjuvant
Colonic Neoplasms
Dactinomycin
Doxorubicin
Drug Resistance
Drug Screening Assays, Antitumor
Female
Flow Cytometry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Mammary Neoplasms, Experimental

Megestrol

Megestrol Acetate

Mice

Mice, Nude

Source

Open in PubMed

Identifiers

PMID: 8194172
DOI: 10.1007/BF00685925

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8194172-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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