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Article

Reversal of the human and murine multidrug-resistance phenotype with megestrol acetate.

Cancer chemotherapy and pharmacology - 1 Jan 1994

Wang L, Yang C P, Horwitz S B, Trail P A, Casazza A M

Abstract excerpt

MA is an orally active PG derivative with an excellent safety profile that is used primarily for the treatment of carcinomas of the breast and endometrium. We investigated the potential application of MA as an MDR-reversal agent using cell culture and human tumor xenograft models. The reversing activity of MA in vitro was compared with that of PG and VER in two human MDR cell lines, the colon carcinoma...

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Identifiers

PMID: 8194172
DOI: 10.1007/BF00685925

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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