Vincristine induction of mutant and wild-type human multidrug-resistance promoters is cell-type-specific and dose-dependent.

doi:10.1007/BF01261403

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Article

Vincristine induction of mutant and wild-type human multidrug-resistance promoters is cell-type-specific and dose-dependent.

Journal of cancer research and clinical oncology - 1 Jan 1996

Stein U, Walther W, Shoemaker R H

Abstract excerpt

To investigate multidrug-resistance gene (MDR1) promoter efficacy and drug inducibility in cells with different multidrug-resistance phenotypes, multidrug-resistant HCT15 and drug-sensitive KM12 human colon carcinoma cell lines were transfected with constructs incorporating the chloramphenicol ac...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Antineoplastic Agents, Phytogenic
Chloramphenicol O-Acetyltransferase
Colonic Neoplasms
Dose-Response Relationship, Drug
Drug Resistance, Multiple
Humans
Mutation
Promoter Regions, Genetic
Tumor Cells, Cultured
Vincristine

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Open in PubMed

Identifiers

PMID: 8609150
DOI: 10.1007/BF01261403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8609150-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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