Medroxyprogesterone-acetate reverses the MDR phenotype of the CG5-doxorubicin resistant human breast cancer cell line.

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Article

Medroxyprogesterone-acetate reverses the MDR phenotype of the CG5-doxorubicin resistant human breast cancer cell line.

Anticancer research - 1 Jan 2000

Zibera C, Gibelli N, Maestri L, Della Cuna G R

Abstract excerpt

In malignant cells multidrug resistance (MDR) is frequently associated with the expression of a 170 KDa P-glycoprotein (P-gp) in the plasma membrane. P-gp acts as an ATP-dependent efflux pump causing a decreased intracellular accumulation of structurally unrelated natural anticancer agents such a...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Breast Neoplasms
Cell Line
Cell Membrane
Cell Survival
Dose-Response Relationship, Drug
Doxorubicin
Drug Resistance, Multiple
Humans
Medroxyprogesterone Acetate
Phenotype
Tumor Cells, Cultured
Verapamil

Source

Open in PubMed

Identifiers

PMID: 7645952

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7645952-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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