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Article

Differential roles of osteopontin/Eta-1 in early and late lpr disease.

Clinical and experimental immunology - 1 Dec 2001

Weber G F, Cantor H

Abstract excerpt

The cytokine osteopontin (Eta-1) leads to macrophage-dependent polyclonal B-cell activation and is induced early in autoimmune prone mice with the lpr mutation, suggesting a significant pathogenic role for this molecule. Indeed, C57BL/6-Fas(lpr/lpr) mice crossed with osteopontin(-/-) mice display delayed onset of polyclonal B-cell activation, as judged by serum immunoglobulin levels. In contrast, they are subject...

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Source

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Identifiers

PMID: 11737079
DOI: 10.1046/j.1365-2249.2001.01702.x
PMCID: PMC1906233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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