Article
Chronic lymphocytic leukemia with isochromosome 17q: An aggressive subgroup associated with TP53 mutations and complex karyotypes.
Cancer letters - 28 Nov 2017
Collado Rosa, Puiggros Anna, López-Guerrero José Antonio, Calasanz Ma José, Larráyoz Ma José, Ivars David, García-Casado Zaida, Abella Eugènia, Orero Ma Teresa, Talavera Elisabet, Oliveira Ana Carla, Hernández-Rivas Jesús Ma, Hernández-Sánchez María, Luño Elisa, Valiente Alberto, Grau Javier, Portal Inmaculada, Gardella Santiago, Salgado Anna Camino, Giménez Ma Teresa, Ardanaz Ma Teresa, Campeny Andrea, Hernández José Julio, Álvarez Sara, Espinet Blanca, Carbonell Félix
Abstract excerpt
Although i(17q) [i(17q)] is frequently detected in hematological malignancies, few studies have assessed its clinical role in chronic lymphocytic leukemia (CLL). We recruited a cohort of 22 CLL patients with i(17q) and described their biological characteristics, mutational status of the genes TP53 and IGHV and genomic complexity. Furthermore, we analyzed the impact of the type of cytogenetic anomaly bearing the...
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