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Article

Correlation between molecular and clinical events in the evolution of chronic myelocytic leukemia to blast crisis.

Blood - 1 Jun 1991

Foti A, Ahuja H G, Allen S L, Koduru P, Schuster M W, Schulman P, Bar-Eli M, Cline M J

Abstract excerpt

A patient with typical Philadelphia chromosome (Ph1)-positive chronic myelocytic leukemia (CML) was studied during sequential phases of disease: (1) initial chronic phase; (2) myeloid blast crisis; (3) second chronic phase; and (4) accelerated disease. A point mutation in the coding sequence of the p53 gene first appeared concomitantly with the blast crisis and then disappeared with the re-establishment of a...

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PMID: 2039825

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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