Article
Correlation between molecular and clinical events in the evolution of chronic myelocytic leukemia to blast crisis.
Blood - 1 Jun 1991
Foti A, Ahuja H G, Allen S L, Koduru P, Schuster M W, Schulman P, Bar-Eli M, Cline M J
Abstract excerpt
A patient with typical Philadelphia chromosome (Ph1)-positive chronic myelocytic leukemia (CML) was studied during sequential phases of disease: (1) initial chronic phase; (2) myeloid blast crisis; (3) second chronic phase; and (4) accelerated disease. A point mutation in the coding sequence of t...
Topics
- Adult
- Base Sequence
- Blast Crisis
- Chromosome Deletion
- DNA
- Exons
- Gene Rearrangement
- Humans
- Introns
- Karyotyping
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Male
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Tumor Suppressor Protein p53