Erythromycin, lincosamides, peptidyl-tRNA dissociation, and ribosome editing.

doi:10.1007/BF00280320

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Article

Erythromycin, lincosamides, peptidyl-tRNA dissociation, and ribosome editing.

Molecular & general genetics : MGG - 1 Apr 1994

Menninger J R, Coleman R A, Tsai L N

Abstract excerpt

Inaccurate protein synthesis produces unstable beta-galactosidase, whose activity is rapidly lost at high temperature. Erythromycin, lincomycin, clindamycin, and celesticetin were shown to counteract the error-inducing effects of streptomycin on beta-galactosidase synthesized in the antibiotic-hypersensitive Escherichia coli strain DB-11 Met-. Newly synthesized beta-galactosidase was more easily inactivated by...

Topics

Anti-Bacterial Agents
Arginine
Bacterial Proteins
Carboxylic Ester Hydrolases
Clindamycin
Culture Media
Erythromycin
Escherichia coli
Hot Temperature
Lincomycin
Methionine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Protein Biosynthesis

RNA, Transfer, Amino Acyl

Ribosomes

Streptomycin

Threonine

beta-Galactosidase

Source

Open in PubMed

Identifiers

PMID: 8177219
DOI: 10.1007/BF00280320

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8177219-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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