Article
The endonuclease activity of RNase III is required for the regulation of antibiotic production by Streptomyces coelicolor.
Microbiology (Reading, England) - 1 Nov 2008
Gravenbeek Marcha L, Jones George H
Abstract excerpt
The double strand-specific endoRNase RNase III globally regulates the production of antibiotics by Streptomyces coelicolor. We have undertaken studies to determine whether the endoRNase activity of S. coelicolor RNase III or its RNA binding activity is responsible for its regulatory function. We show that an rnc null mutant of S. coelicolor M145 does not produce actinorhodin or undecylprodigiosin. Restoring a...
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