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Article

A key developmental regulator controls the synthesis of the antibiotic erythromycin in <i>Saccharopolyspora erythraea</i>

6 Aug 2008

Abstract excerpt

Saccharopolyspora erythraea makes erythromycin, an antibiotic commonly used in human medicine. Unusually, the erythromycin biosynthetic (ery) cluster lacks a pathway-specific regulatory gene. We isolated a transcriptional regulator of the ery biosynthetic genes from S. erythraea and found that this protein appears to directly link morphological changes caused by impending starvation to the synthesis of a molecule...

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PMID: 18685110
DOI: 10.1073/pnas.0803622105

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