Lincosamide antibiotics stimulate dissociation of peptidyl-tRNA from ribosomes.

doi:10.1128/AAC.37.9.2027

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Article

Lincosamide antibiotics stimulate dissociation of peptidyl-tRNA from ribosomes.

Antimicrobial agents and chemotherapy - 1 Sept 1993

Menninger J R, Coleman R A

Abstract excerpt

At nonpermissive temperatures the peptidyl-tRNA hydrolase of pth(Ts) bacterial mutants is inactivated, and cells accumulate peptidyl-tRNA and die. Doses of erythromycin, lincomycin, or clindamycin that inhibited the growth of antibiotic-hypersensitive DB-11 pth+ cells accelerated the killing of D...

Topics

Anti-Bacterial Agents
Carboxylic Ester Hydrolases
Clindamycin
Erythromycin
Escherichia coli
Lincomycin
Lincosamides
Macrolides
Mutation
RNA, Transfer, Amino Acyl
Ribosomes
Temperature

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