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Article

Lincosamide antibiotics stimulate dissociation of peptidyl-tRNA from ribosomes.

Antimicrobial agents and chemotherapy - 1 Sept 1993

Menninger J R, Coleman R A

Abstract excerpt

At nonpermissive temperatures the peptidyl-tRNA hydrolase of pth(Ts) bacterial mutants is inactivated, and cells accumulate peptidyl-tRNA and die. Doses of erythromycin, lincomycin, or clindamycin that inhibited the growth of antibiotic-hypersensitive DB-11 pth+ cells accelerated the killing of DB-11 pth(Ts) cells at nonpermissive temperatures. Erythromycin and lincomycin also stimulated the accumulation of...

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Identifiers

PMID: 8239627
DOI: 10.1128/AAC.37.9.2027
PMCID: PMC188116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lincosamide antibiotics stimulate dissociation of peptidyl-tRNA from ribosomes.PMID 8239627Read ↗

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