Article
The construction and characterization of poliovirus antigen chimeras presenting defined regions of the human T lymphocyte marker CD4.
The Journal of general virology - 1 May 1994
Rose C, Andrews W, Ferguson M, McKeating J, Almond J, Evans D
Abstract excerpt
Defined regions of the CDR2-like region of the T cell antigen CD4 that are implicated in the binding of the surface glycoprotein (gp120) of human immunodeficiency virus type 1 (HIV-1) to CD4+ T lymphocytes have been engineered in place of antigenic site 1 of Sabin type 1 poliovirus. The antigenic...
Topics
- Amino Acid Sequence
- Antibodies, Monoclonal
- Antibody Formation
- Antibody Specificity
- Base Sequence
- CD4 Antigens
- Capsid
- Capsid Proteins
- HIV Envelope Protein gp120
- Molecular Sequence Data
- Mutation
- Neutralization Tests
- Poliovirus
- Protein Binding
- Recombinant Fusion Proteins