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Article

Molecular basis for linkage of a continuous and discontinuous neutralization epitope on the structural polypeptide VP2 of poliovirus type 1.

Journal of virology - 1 Mar 1990

Wiegers K J, Wetz K, Dernick R

Abstract excerpt

We obtained neutralizing monoclonal antibodies against a continuous neutralization epitope on VP2 of poliovirus type 1 strain Mahoney by using a combined in vivo-in vitro immunization procedure. The antibody-binding site was mapped to amino acid residues within the peptide segment (residues 164 through 170) of VP2 by competition with synthetic peptide and sequencing of resistant mutants. Cross-neutralization of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 1689392
DOI: 10.1128/JVI.64.3.1283-1289.1990
PMCID: PMC249245

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Source receipt: pubmed, retrieved 7 Sept 2026.

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