Molecular basis for linkage of a continuous and discontinuous neutralization epitope on the structural polypeptide VP2 of poliovirus type 1.

doi:10.1128/JVI.64.3.1283-1289.1990

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Article

Molecular basis for linkage of a continuous and discontinuous neutralization epitope on the structural polypeptide VP2 of poliovirus type 1.

Journal of virology - 1 Mar 1990

Wiegers K J, Wetz K, Dernick R

Abstract excerpt

We obtained neutralizing monoclonal antibodies against a continuous neutralization epitope on VP2 of poliovirus type 1 strain Mahoney by using a combined in vivo-in vitro immunization procedure. The antibody-binding site was mapped to amino acid residues within the peptide segment (residues 164 t...

Topics

Amino Acid Sequence
Antibodies, Monoclonal
Capsid
Capsid Proteins
Cross Reactions
Epitopes
Genetic Variation
HeLa Cells
Humans
Molecular Sequence Data
Mutation
Neutralization Tests
Poliovirus

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