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Article

Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity

12 Dec 2018

Abstract excerpt

Sequence variability in surface-antigenic sites of pathogenic proteins is an important obstacle in vaccine development. Over 200 distinct genomic sequences have been identified for human papillomavirus (HPV), of which more than 18 are associated with cervical cancer. Here, based on the high structural similarity of L1 surface loops within a group of phylogenetically close HPV types, we design a triple-type...

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PMID: 30560935
DOI: 10.1038/s41467-018-07199-6

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