Characterization of a conserved T cell epitope in HIV-1 gp41 recognized by vaccine-induced human cytolytic T cells.

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Article

Characterization of a conserved T cell epitope in HIV-1 gp41 recognized by vaccine-induced human cytolytic T cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 1991

Hammond S A, Obah E, Stanhope P, Monell C R, Strand M, Robbins F M, Bias W B, Karr R W, Koenig S, Siliciano R F

Abstract excerpt

A human CTL epitope located in a region of the HIV-1 envelope protein gp41 that is highly conserved among various HIV-1 strains was identified. This epitope was recognized by CD4+ CTL clones that were induced in seronegative humans by immunization with recombinant gp160. Fusion proteins carrying...

Topics

Amino Acid Sequence
CD4-Positive T-Lymphocytes
Clone Cells
Epitopes
Genetic Variation
HIV Envelope Protein gp41
Humans
Immunosuppression Therapy
Molecular Sequence Data
T-Lymphocytes, Cytotoxic

Source

Open in PubMed

Identifiers

PMID: 1704395

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1704395-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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