Article
Purification and characterisation of a brain-derived neurotrophic factor/neurotrophin-3 (BDNF/NT-3) heterodimer.
European journal of biochemistry - 15 Apr 1994
Jungbluth S, Bailey K, Barde Y A
Abstract excerpt
The neurotrophins nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) are known to exist in solution as non-covalently linked homodimeric proteins. The recent elucidation of the crystal structure of the NGF homodimer, as well as the conservation of struc...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Western
- Brain-Derived Neurotrophic Factor
- Cell Line
- Cell Survival
- Chick Embryo
- Mice
- Molecular Sequence Data
- Mutation
- Nerve Growth Factors
- Nerve Tissue Proteins
- Neurons
- Neurotrophin 3
- Polymers
- Rabbits
- Receptor Protein-Tyrosine Kinases