Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TrkB activation by brain-derived neurotrophic factor inhibits the G protein-gated inward rectifier Kir3 by tyrosine phosphorylation of the channel.

The Journal of biological chemistry - 18 Aug 2000

Rogalski S L, Appleyard S M, Pattillo A, Terman G W, Chavkin C

Abstract excerpt

G protein-activated inwardly rectifying potassium channels (Kir3) are widely expressed throughout the brain, and regulation of their activity modifies neuronal excitability and synaptic transmission. In this study, we show that the neurotrophin brain-derived neurotrophic factor (BDNF), through activation of TrkB receptors, strongly inhibited the basal activity of Kir3. This inhibition was subunit dependent as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carbazoles
Share to G Protein-Coupled Inwardly-Rectifying Potassium Channels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genistein

Share to Potassium Channels

Share to Potassium Channels, Inwardly Rectifying

Share to Receptor, trkB

Share to Staurosporine

Share to Xenopus

Source

Open in PubMed Open full text

Identifiers

PMID: 10833508
DOI: 10.1074/jbc.M000183200
PMCID: PMC1276699

Genes

BDNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TrkB activation by brain-derived neurotrophic factor inhibits the G protein-gated inward rectifier Kir3 by tyrosine phosphorylation of the channel.PMID 10833508Read ↗

Evidence for a non-canonical JAK/STAT signaling pathway in the synthesis of the brain’s major ion channels and neurotransmitter receptorsSemantic proximity Read ↗

JIP3 mediates TrkB axonal anterograde transport and enhances BDNF signaling by directly bridging TrkB with kinesin-1.Semantic proximity Read ↗

BDNF: An Oncogene or Tumor Suppressor?Semantic proximity Read ↗

BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization.Semantic proximity Read ↗

Sequential phosphorylation mediates receptor- and kinase-induced inhibition of TREK-1 background potassium channels.Semantic proximity Read ↗

The ability of BDNF to modify neurogenesis and depressive-like behaviors is dependent upon phosphorylation of tyrosine residues 365/367 in the GABA(A)-receptor γ2 subunit.Semantic proximity Read ↗

The secreted brain-derived neurotrophic factor precursor pro-BDNF binds to TrkB and p75NTR but not to TrkA or TrkC.Semantic proximity Read ↗

A synaptic locus for TrkB signaling underlying ketamine rapid antidepressant actionSemantic proximity Read ↗

BDNF modulates heart contraction force and long-term homeostasis through truncated TrkB.T1 receptor activation.Semantic proximity Read ↗

Brain-derived neurotrophic factor but not vesicular zinc promotes TrkB activation within mossy fibers of mouse hippocampus in vivo.Semantic proximity Read ↗

Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model.Semantic proximity Read ↗

Genistein and tyrphostin AG556 inhibit inwardly-rectifying Kir2.1 channels expressed in HEK 293 cells via protein tyrosine kinase inhibition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.