Down-regulation of bcl-2 by p53 in breast cancer cells.

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Article

Down-regulation of bcl-2 by p53 in breast cancer cells.

Cancer research - 15 Apr 1994

Haldar S, Negrini M, Monne M, Sabbioni S, Croce C M

Abstract excerpt

bcl-2 and p53 gene products have been both linked to programmed cell death pathways. We have analyzed several human breast cancer cell lines for the expression of bcl-2 and p53. We found an inverse correlation between the expression of the two proteins. The result suggested that mutant p53 could substitute for bcl-2 function in breast cancer cells and that could also down-regulate bcl-2 expression. We found,...

Topics

Alleles
Base Sequence
Breast Neoplasms
Cell Line
Codon
Female
Gene Expression
Gene Expression Regulation, Neoplastic
Genes, p53
Humans
Point Mutation
Promoter Regions, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein-Tyrosine Kinases

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-bcl-2

Proto-Oncogenes

Transfection

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 8174112

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8174112-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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