Article
Anti-Her-2/neu antibody induces apoptosis in Her-2/neu overexpressing breast cancer cells independently from p53 status.
British journal of cancer - 30 Nov 2001
Brodowicz T, Kandioler D, Tomek S, Ludwig C, Rudas M, Kunstfeld R, Koestler W, Hejna M, Budinsky A, Wiltschke C, Zielinski C C
Abstract excerpt
Anti-Her-2/neu antibody is known to induce apoptosis in HER-2/neu overexpressing breast cancer cells. However, exact regulatory mechanisms mediating and controlling this phenomenon are still unknown. In the present study, we have investigated the effect of anti-Her-2/neu antibody on apoptosis of HER-2/neu overexpressing human breast cancer cell lines SK-BR-3, HTB-24, HTB-25, HTB-27, HTB-128, HTB-130 and HTB-131...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.