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17β-Estradiol Inhibits Apoptosis in MCF-7 Cells, Inducing <i>bcl-2</i> Expression via Two Estrogen-Responsive Elements Present in the Coding Sequence

1 Apr 2000

Abstract excerpt

We have found that 17beta-estradiol induces bcl-2 transcription in human breast cancer MCF-7 cells. To identify cis-acting elements involved in this regulation, we have analyzed hormone responsiveness of transiently transfected reporter constructs containing the bcl-2 major promoter (P(1)). Hormone inducibility was observed only when either of two sequences, located within the bcl-2 coding region and showing one...

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Identifiers

PMID: 10733592
DOI: 10.1128/mcb.20.8.2890-2901.2000

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