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Article

Cytoplasmic mutant p53 increases Bcl-2 expression in estrogen receptor-positive breast cancer cells.

Apoptosis : an international journal on programmed cell death - 1 Apr 2007

Pratt M A Christine, White Dawn, Kushwaha Neena, Tibbo Emma, Niu Min Ying

Abstract excerpt

The Bcl-2 gene is positively regulated by estrogen (E2) primarily through E2-response elements in the coding region and a putative p53 negative regulatory element (NRE) containing a short upstream open reading frame (uORF). The ability of mutant p53 to repress or induce Bcl-2 expression is controversial. In this study E2-receptor positive (ER(+))/wild-type p53 MCF-7cells were transfected with p53Delta291, which...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Proto-Oncogene Proteins c-bcl-2

Share to Receptors, Estrogen

Share to Regulatory Sequences, Nucleic Acid

Share to Transcription, Genetic

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 17252199
DOI: 10.1007/s10495-006-0023-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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