Article
Analysis of bcl-2 in sporadic breast carcinoma.
Cancer - 1 Dec 1997
Dueñas-González A, Abad-Hernández M M, Cruz-Hernández J J, González-Sarmiento R
Abstract excerpt
BACKGROUND: The bcl-2 gene encodes a protein that blocks apoptosis and might help to promote tumor development. It is expressed in a high percentage of breast tumors and is associated with good prognostic features. However, the mechanisms that regulate bcl-2 expression in breast carcinoma are unk...
Topics
- Blotting, Southern
- Breast Neoplasms
- Down-Regulation
- Female
- Gene Expression Regulation, Neoplastic
- Genes, bcl-2
- Genes, p53
- Humans
- Loss of Heterozygosity
- Methylation
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Proto-Oncogene Proteins c-bcl-2
- Tumor Suppressor Protein p53