Article
Analysis of bcl-2 in sporadic breast carcinoma.
Cancer - 1 Dec 1997
Dueñas-González A, Abad-Hernández M M, Cruz-Hernández J J, González-Sarmiento R
Abstract excerpt
BACKGROUND: The bcl-2 gene encodes a protein that blocks apoptosis and might help to promote tumor development. It is expressed in a high percentage of breast tumors and is associated with good prognostic features. However, the mechanisms that regulate bcl-2 expression in breast carcinoma are unknown. Moreover, immunohistochemical detection of bcl-2 is related inversely to p53 expression. This notwithstanding,...
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